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What is trilostane?

Trilostane (brand name Vetoryl®) is used for the treatment of (Cushing’s disease)  in dogs and cats and (Alopecia X) in dogs.


How to give trilostane to your pet?

Trilostane is given orally in capsule form with food, and preferably in the morning if once daily dosing. This medication should take effect within 1 to 2 days.


What are the potential side effects?

Trilostane generally is well-tolerated; however, your pet might show signs of lethargy, vomiting, diarrhea, and lack of appetite during the first few days of therapy. Reducing the dose and slowly increasing to the recommended schedule may reduce the side effects. Speak to your veterinarian if your pet experiences these sings. These side effects are usually mild and resolve on their own.

Hypoadrenocorticism can occur and is usually reversible once the medication is discontinued, but in very rare cases, adrenal gland damage and death can occur in dogs.

In cats, side effects include lethargy, anorexia, and dulled mental activity.

A life-threatening condition, called an Addisonian crisis, can occur while using this medication. Your pet should be monitored closely for vomiting, diarrhea, lethargy, shaking, increased drinking or urination, weakness, or collapse.


Are there any drug interactions I should be aware of?

Trilostane should be used with caution when given with the following drugs: ACE inhibitors (such as benazepril or enalapril), aminoglutethimide, ketoconazole, mitotane, potassium-sparing diuretics (spironolactone), and potassium supplements.

Be sure to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your pet is taking.


Is there any monitoring that needs to be done with this medication?

You should monitor your pet closely for adverse effects. After starting the medication, frequent and regular rechecks with your veterinarian are important. Adrenocorticotropic hormone (ACTH) stimulation tests and other laboratory tests will be needed to monitor for adverse effects, efficacy, and dose appropriateness.


How do I store trilostane?

Trilostane capsules should be stored in tight, light-resistant containers at room temperature 25°C


What should I do in case of emergency?

In the case of an Addisonian crisis, glucocorticoids should be administered immediately, followed by veterinary care. Your veterinarian should provide you with an emergency supply of glucocorticoids as a precaution.

If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.


What is Cushing’s disease?

Cushing’s disease (hyperadrenocorticism) is caused by excess corticosteroid. Animals with Cushing’s disease usually present to the veterinarian with clinical signs that may include increased thirst and urination, excessive hunger, weight gain, decreased activity, chronic skin infections, hair loss, and occasionally, behavior changes.

In the dog, about 85% of cases of Cushing’s disease are due to pituitary-dependant hyperadrenocorticism (PDH). PDH is caused by a benign tumor on the pituitary gland, which overstimulates the adrenal gland. PDH is a disease of middle-aged dogs and some breeds, including West Highland White Terriers, Poodles, Dachshunds, Boston Terriers and Boxers, have a higher incidence of PDH. Less common causes of Cushing’s disease include malignant or benign tumors of the adrenal gland and overuse of corticosteroid drugs.

Living with a Dog with Cushing’s Disease:

Once your dog has begun treatment with medication for cushings disease you need to be prepared to continue medication for the life of your pet. You will need to be observant for any adverse reactions to these medications. Typical signs of an adverse reaction are – lack of energy, weakness, lack of appetite, vomiting, diarrhoea, and sometimes difficulty walking. If any of these side effects should occur you should discontinue the medication and contact you vet immediately. your vet may also prescribe some corticosteroid medication to be used in these circumstances, or during periods of stress in which your pet may need additional cortisol to respond to the situation.




Compounding is the art and science of preparing customised medications for patients.

Solving dosage problems

Just like their owners, animals are individual and unique. They come in different shapes and sizes, and as a result, not all commercially available medicines are appropriate for every pet. That’s where compounding is especially helpful. In this situation, your veterinarian can prescribe the specific amount of medication that is exactly right for your pet’s size and condition.

Flavoured Medicine

A pet who refuses to take medication because of the taste is a prime opportunity for compounding. Cats don’t like pills, but they do like tuna. Dogs don’t appreciate a traditional solution of medication being squirted into their mouth, but they’ll take it gladly when it’s flavored with meat or part of a tasty biscuit or treat. By working closely with your veterinarian, a compounding pharmacist can prepare medicines in easy-to-give flavored dosage forms that animals happily take.

Commercially Unavailable Medicine

From time to time, a manufacturer may discontinue a veterinary medication. Often this is because it is not needed in the vast quantities necessary to make mass production cost-effective, but that doesn’t mean there aren’t still some pets that need it. When that medication has worked well for animals, a compounding pharmacist can prepare a prescription for the discontinued product – and tailor the strength, dosage form, and flavour to that pet’s specific needs.

Products include tablets, capsules, liquids and transdermal gels for a variety of medications. 

We do not compound medicines, however we can organise for a PCCA approved compounding pharmacy to tailor a solution for your pet's individual requirements.

Please email and make sure to attach your pet's prescription so you may be accurately quoted, or phone us on 02 89372254.

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